Rethinking the role of the immune system in multiple sclerosis

In a plenary lecture at the MSVirtual 2020 meeting, Prof Stefan Bittner of the University Medical Center of the Johannes Gutenberg University in Mainz, Germany, outlined the latest research on immunology and multiple sclerosis (MS).

Prof Bittner reviewed 4 key areas of research:

    Role of glial cells: “This is an exciting area that is expanding rapidly and will continue to expand in the next few years,” Prof Bittner noted. He highlighted research on the beneficial effects of microglial engulfment of T cells, which reduces early CNS inflammation. A pathologically relevant subset of monocytes (Cxcl10+) has also been identified. “We are now going beyond data collection to the interpretation of the data and how it relates to pathophysiology,” Prof Bittner said.